Expression of E-cadherin and B-cell lymphoma 2 in oral cancer: A ratio-based planning for targeted therapy.

Abstract

BACKGROUND:

Oral cancer is known to be governed by the antiapototic and loss of cell adhesion properties which dictate its progression.

AIM:

To study the immunexpression of E-cadherin and Bcl-2 in varying TNM stages and histopathological grades of OSCC.

MATERIALS AND METHODS:

11 cases of well differentiated, 10 cases of moderately differentiated and 11 cases of poorly differentiated OSCC were studied immunohistochemically using archival paraffin embedded tissue specimens.

STATISTICAL ANALYSIS:

Differences between the different variables were analyzed using ANOVA test, Kruskal-Wallis test and post hoc test followed by Bonferroni test. The resulting data was analyzed using SPSS software version 19.

RESULTS:

The expression of Bcl-2 and E cadherin immunopositivity was associated positively with tumor grade, high T category and Histopathological grades.

CONCLUSIONS:

The results of this study points to the significance of cell proliferation and invasion as a major determinant of prognosis in OSCC.

• Authors: Nikita Gulati, Ajit Singh Rathore, Saurabh Juneja, Priyanka Rastogi
• Journal: Indian journal of dental research : official publication of Indian Society for Dental Research (Indian J Dent Res) 2017 Jan-Feb Vol. 28 Issue 1 Pg. 3-9 ISSN: 1998-3603 [Electronic] India
• PMID: 28393810 (Publication Type: Journal Article)

Chemical References

• BCL2 protein, human
• Cadherins
• Proto-Oncogene Proteins c-bcl-2

Topics

• Cadherins (analysis, antagonists & inhibitors, genetics)
• Carcinoma, Squamous Cell (drug therapy, genetics, immunology, pathology)
• Cell Transformation, Neoplastic (drug effects, genetics, immunology, pathology)
• DNA Mutational Analysis
• Developing Countries
• Humans
• India
• Molecular Targeted Therapy
• Mouth Neoplasms (drug therapy, genetics, immunology, pathology)
• Neoplasm Grading
• Neoplasm Invasiveness
• Neoplasm Staging
• Proto-Oncogene Proteins c-bcl-2 (analysis, antagonists & inhibitors, genetics)