Abstract | OBJECTIVE: DESIGN: We prospectively evaluated the association between antibiotic use at age 20-39 and 40-59 (assessed in 2004) and recent antibiotic use (assessed in 2008) with risk of subsequent colorectal adenoma among 16 642 women aged ≥60 enrolled in the Nurses' Health Study who underwent at least one colonoscopy through 2010. We used multivariate logistic regression to calculate ORs and 95% CIs. RESULTS: We documented 1195 cases of adenoma. Increasing duration of antibiotic use at age 20-39 (ptrend=0.002) and 40-59 (ptrend=0.001) was significantly associated with an increased risk of colorectal adenoma. Compared with non-users, women who used antibiotics for ≥2 months between age 20 and 39 had a multivariable OR of 1.36 (95% CI 1.03 to 1.79). Women who used ≥2 months of antibiotics between age 40 and 59 had a multivariable OR of 1.69 (95% CI 1.24 to 2.31). The associations were similar for low-risk versus high-risk adenomas (size ≥1 cm, or with tubulovillous/villous histology, or ≥3 detected lesions), but appeared modestly stronger for proximal compared with distal adenomas. In contrast, recent antibiotic use within the past four years was not associated with risk of adenoma (ptrend=0.44). CONCLUSIONS: Long-term antibiotic use in early-to-middle adulthood was associated with increased risk of colorectal adenoma.
|
Authors | Yin Cao, Kana Wu, Raaj Mehta, David A Drew, Mingyang Song, Paul Lochhead, Long H Nguyen, Jacques Izard, Charles S Fuchs, Wendy S Garrett, Curtis Huttenhower, Shuji Ogino, Edward L Giovannucci, Andrew T Chan |
Journal | Gut
(Gut)
Vol. 67
Issue 4
Pg. 672-678
(04 2018)
ISSN: 1468-3288 [Electronic] England |
PMID | 28377387
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Copyright | Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/. |
Chemical References |
|
Topics |
- Adenoma
(chemically induced, epidemiology, nursing, pathology)
- Adult
- Anti-Bacterial Agents
(adverse effects)
- Colonoscopy
(nursing)
- Colorectal Neoplasms
(chemically induced, epidemiology, nursing, pathology)
- Female
- Humans
- Middle Aged
- Nursing Research
- Predictive Value of Tests
- Prospective Studies
- Risk Factors
- Sensitivity and Specificity
- Time Factors
- United States
(epidemiology)
|