Abstract | OBJECTIVE: METHODS: RESULTS: The positivity rate of DAPK methylation was significantly higher in ALL patients (29.1%) than in AML patients group (5%) and normal subjects (0%) (P<0.01). No correlation was found between DAPK gene methylation and the clinical features in ALL patients (P>0.05). DAPK mRNA expression level differed significantly among the 3 groups (P=0.000), and was the highest in normal subjects and the lowest in ALL patients. In ALL patients, the expression level of DAPK mRNA showed a significant inverse correlation with DAPK promoter methylation (P<0.05). CONCLUSION: The methylation rate of DAPK gene is higher in untreated ALL patients than in AML patients and normal subjects. DAPK gene methylation is not correlated with the clinical features of ALL patients but is probably related with the low gene expression level of DAPK in these patients.
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Authors | Wei-Hua Zhao, Fan-Yi Meng, Yong-Rong Lai, Zhi-Gang Peng, Jie Ma |
Journal | Nan fang yi ke da xue xue bao = Journal of Southern Medical University
(Nan Fang Yi Ke Da Xue Xue Bao)
Vol. 37
Issue 3
Pg. 407-410
(Mar 20 2017)
ISSN: 1673-4254 [Print] China |
PMID | 28377362
(Publication Type: Journal Article)
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Chemical References |
- Death-Associated Protein Kinases
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Topics |
- Case-Control Studies
- DNA Methylation
- Death-Associated Protein Kinases
(genetics, metabolism)
- Humans
- Leukemia, Myeloid, Acute
(genetics, metabolism)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(genetics, metabolism)
- Promoter Regions, Genetic
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