Abstract | BACKGROUND: The worldwide incidence of esophageal cancer has greatly increased over the past few decades making it the sixth deadliest cancer. The disease is often detected in advanced stages when surgery is no longer an option. The standard treatment in these situations is combined chemoradiotherapy, by employing drug cocktails that lead to optimal treatment outcomes both from the perspective of tumor control and normal tissue toxicity. METHODS: The aim of this work was to collate the existing trials and clinical studies reported on non-operable esophageal cancer and to analyze the results based on treatment outcomes after various drug combinations. RESULTS: CONCLUSIONS: More research is warranted to further increase the therapeutic ratio in non-operable esophageal cancers.
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Authors | Bianca So, Loredana G Marcu, Ian Olver, Raghu Gowda, Eva Bezak |
Journal | Acta oncologica (Stockholm, Sweden)
(Acta Oncol)
Vol. 56
Issue 7
Pg. 899-908
(Jul 2017)
ISSN: 1651-226X [Electronic] England |
PMID | 28375694
(Publication Type: Journal Article, Review)
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Esophageal Neoplasms
(drug therapy)
- Humans
- Neoadjuvant Therapy
- Prognosis
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