B-vitamin Supplementation Mitigates Effects of Fine Particles on Cardiac Autonomic Dysfunction and Inflammation: A Pilot Human Intervention Trial.

Abstract

Ambient fine particle (PM2.5) pollution triggers acute cardiovascular events. Individual-level preventions are proposed to complement regulation in reducing the global burden of PM2.5-induced cardiovascular diseases. We determine whether B vitamin supplementation mitigates PM2.5 effects on cardiac autonomic dysfunction and inflammation in a single-blind placebo-controlled crossover pilot trial. Ten healthy adults received two-hour controlled-exposure-experiment to sham under placebo, PM2.5 (250 μg/m3) under placebo, and PM2.5 (250 μg/m3) under B-vitamin supplementation (2.5 mg/d folic acid, 50 mg/d vitamin B6, and 1 mg/d vitamin B12), respectively. At pre-, post-, 24 h-post-exposure, we measured resting heart rate (HR) and heart rate variability (HRV) with electrocardiogram, and white blood cell (WBC) counts with hematology analyzer. Compared to sham, PM2.5 exposure increased HR (3.8 bpm, 95% CI: 0.3, 7.4; P = 0.04), total WBC count (11.5%, 95% CI: 0.3%, 24.0%; P = 0.04), lymphocyte count (12.9%, 95% CI: 4.4%, 22.1%; P = 0.005), and reduced low-frequency power (57.5%, 95% CI: 2.5%, 81.5%; P = 0.04). B-vitamin supplementation attenuated PM2.5 effect on HR by 150% (P = 0.003), low-frequency power by 90% (P = 0.01), total WBC count by 139% (P = 0.006), and lymphocyte count by 106% (P = 0.02). In healthy adults, two-hour PM2.5 exposure substantially increases HR, reduces HRV, and increases WBC. These effects are reduced by B vitamin supplementation.

• Authors: Jia Zhong, Letizia Trevisi, Bruce Urch, Xinyi Lin, Mary Speck, Brent A Coull, Gary Liss, Aaron Thompson, Shaowei Wu, Ander Wilson, Petros Koutrakis, Frances Silverman, Diane R Gold, Andrea A Baccarelli
• Journal: Scientific reports (Sci Rep) Vol. 7 Pg. 45322 (04 03 2017) ISSN: 2045-2322 [Electronic] England
• PMID: 28367952 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Particulate Matter
• Vitamin B Complex
• Vitamin B 6
• Folic Acid
• Vitamin B 12

Topics

• Adult
• Autonomic Nervous System (drug effects)
• Cross-Over Studies
• Electrocardiography
• Female
• Folic Acid (administration & dosage, pharmacology)
• Heart Rate (drug effects)
• Humans
• Inflammation (chemically induced, prevention & control)
• Lymphocyte Count
• Male
• Middle Aged
• Particle Size
• Particulate Matter (adverse effects)
• Pilot Projects
• Single-Blind Method
• Vitamin B 12 (administration & dosage, pharmacology)
• Vitamin B 6 (administration & dosage, pharmacology)
• Vitamin B Complex (administration & dosage, pharmacology)
• Young Adult