Abstract | BACKGROUND: METHODS: We searched the PubMed, ScienceDirect and Web of Science databases for published literature investigating associations between stromal caveolin-1 expression and survival outcome in breast cancer patients. With respect to survival outcomes, the pooled hazard ratios (HRs) of caveolin-1 and the 95% confidence intervals (CI) were calculated. RESULTS: Our meta-analysis identified a total of 10 studies involving 2072 cases. Further investigation demonstrated that a lack of caveolin-1 expression in the breast cancer stroma is a hazard for overall survival (OS) (HR = 2.33, 95% CI: 1.57-3.46) and disease-free/progression-free survival (DFS/PFS) (HR = 3.05, 95% CI: 2.26-4.12) in breast cancer patients. Moreover, lack of caveolin-1 expression in the cancer-associated fibroblasts was a significant predictor of DFS/PFS (HR = 2.79, 95% CI: 1.75-4.46). CONCLUSION: Our results indicated that lack of expression of caveolin-1 in the breast cancer stroma is associated with a poor prognosis.
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Authors | Xiuying Li, Jinfan Sun, Shuenqin Hu |
Journal | Wiener klinische Wochenschrift
(Wien Klin Wochenschr)
Vol. 129
Issue 15-16
Pg. 558-563
(Aug 2017)
ISSN: 1613-7671 [Electronic] Austria |
PMID | 28364168
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- Biomarkers, Tumor
- Caveolin 1
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Topics |
- Biomarkers, Tumor
(genetics)
- Breast
(pathology)
- Breast Neoplasms
(diagnosis, genetics, mortality, pathology)
- Caveolin 1
(genetics)
- Confidence Intervals
- Correlation of Data
- Female
- Fibroblasts
(pathology)
- Follow-Up Studies
- Humans
- Kaplan-Meier Estimate
- Mesoderm
(pathology)
- Middle Aged
- Prognosis
- Proportional Hazards Models
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