Abstract |
Sixteen patients with medullary sponge kidney (MSK) and renal stones underwent evaluation of calcium metabolism and acid base balance. Six normal subjects and eight patients with non-MSK absorptive hypercalciuria served as control. Nine (56%) were hypercalciuric and seven (44%) were normocalciuric (N-MSK). Hypercalciuria was divided into absorptive (AH-MSK, n = 2) and renal leak hyerpcalciuria (RH-MSK, n = 7). The mean of minimal urine pH of RH-MSK group (5.28 +/- 0.09 (SE] was significantly higher than that of normal control (4.78 +/- 0.12) and of non-MSK AH (4.80 +/- 0.6) during acute acid challenge. The mean of the arterial blood HCO3 concentration of RH-MSK group was significantly lower than that of two control groups. The urine calcium and a frequency of stone passage were decreased significantly after alkali treatment in RH-MSK.
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Authors | E Higashihara, K Nutahara, T Niijima |
Journal | Urological research
(Urol Res)
Vol. 16
Issue 2
Pg. 95-100
( 1988)
ISSN: 0300-5623 [Print] Germany |
PMID | 2835848
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bicarbonates
- Phosphates
- Sodium Bicarbonate
- Sodium
- Cyclic AMP
- Calcium
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Topics |
- Acid-Base Equilibrium
- Acidosis
(complications, drug therapy)
- Adult
- Bicarbonates
(therapeutic use)
- Calcium
(blood, urine)
- Cyclic AMP
(urine)
- Female
- Humans
- Kidney Calculi
(complications, drug therapy)
- Male
- Medullary Sponge Kidney
(complications)
- Phosphates
(blood)
- Sodium
(therapeutic use)
- Sodium Bicarbonate
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