The treatment of malignant
tumors following surgery is important in preventing relapse. Among all the post-surgery treatments,
immunomodulators have demonstrated satisfactory effects on preventing recurrence according to recent studies.
Ginsenoside is a compound isolated from panax ginseng, which is a famous
traditional Chinese medicine.
Ginsenoside aids in killing
tumor cells through numerous processes, including the antitumor processes of
ginsenoside Rh2 and Rg1, and also affects the inflammatory processes of the immune system. However, the role that
ginsenoside serves in antitumor immunological activity remains to be elucidated. Therefore, the present study aimed to analyze the effect of
ginsenoside Rh2 on the antitumor immunological response. With a
melanoma mice model,
ginsenoside Rh2 was demonstrated to inhibit
tumor growth and improved the survival time of the mice.
Ginsenoside Rh2 enhanced T-lymphocyte infiltration in the
tumor and triggered cytotoxicity in spleen lymphocytes. In addition, the immunological response triggered by
ginsenoside Rh2 could be transferred to other mice. In conclusion, the present study provides evidence that
ginsenoside Rh2 treatment enhanced the antitumor immunological response, which may be a potential
therapy for
melanoma.