Anticoagulation therapy for a LVAD patient with acquired warfarin resistance.

Abstract

Anticoagulation therapy with warfarin is essential for postoperative management in patients with left ventricular assist device (LVAD). In this manuscript, we report the case of a patient who developed warfarin resistance after LVAD implantation. Although we administered a novel anticoagulant drug in addition to warfarin and aspirin therapy, the patient developed a major stroke. The patient needed continuous intravenous heparinization until heart transplantation for approximately 2 years. Meticulous management of anticoagulation therapy is essential for a LVAD with warfarin resistance. To our best knowledge, our case is the first case of warfarin resistance in a patient with LVAD.

• Authors: Daisuke Yoshioka, Koichi Toda, Takayuki Hidaka, Soichiro Yasuda, Shunsuke Saito, Keitaro Domae, Yoshiki Sawa
• Journal: Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs (J Artif Organs) Vol. 20 Issue 3 Pg. 260-262 (Sep 2017) ISSN: 1619-0904 [Electronic] Japan
• PMID: 28349222 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticoagulants
• Heparin

Topics

• Adult
• Anticoagulants (therapeutic use)
• Heart Failure (therapy)
• Heart Transplantation
• Heart-Assist Devices
• Heparin (therapeutic use)
• Humans
• Male
• Metabolism, Inborn Errors
• Stroke (surgery)