Abstract | OBJECTIVE: DESIGN: Comparative cohort study of 1368 pregnancies from three cohorts gathered before (1996-1998), during (2000-2003) and after (2008-2009) the iodine fortification program. METHODS: In cohort 1 (n = 297), TPOAbs were measured (DYNOtest (BRAHMS)). In cohorts 2 (n = 148) and 3 (n = 923), both TPOAbs and TgAbs were measured (Kryptor immunofluorescent assay (BRAHMS)). The prevalence and effect of antibody positivity were explored using three cut-offs: TPOAbs and/or TgAbs >100 kU/L, TPOAbs and/or TgAbs >60 kU/L and TPOAbs >30 and/or TgAbs >20 kU/L. National preterm birth data were extracted from the National Birth Registry. RESULTS: In the three cohorts, TPOAb levels >60 kU/L were found in 5.4, 8.1 and 12.0% (χ2(2, n = 1367) = 11.7, P = 0.003) respectively, and TPOAbs and/or TgAbs >60 kU/L in 8.1 and 16.2% in cohorts 2 and 3 respectively (χ2(2, n = 1070) = 6.5, P = 0.01). TgAb levels (>20 kU/L) had increased plenty-fold from cohort 2 to 3 (χ2(1, n = 1071) = 136.5, P < 0.001). Preterm birth occurred in 4.1% of all pregnancies with no effect from antibody positivity (TPOAbs and/or TgAbs >60 kU/L, χ2(1, n = 1039) = 0.0, P = 0.98, aOR = 1.1, 95% CI (0.4-2.7)). The national preterm birth-rate showed no increase over the same period. CONCLUSIONS: Thyroid antibody positivity in Danish pregnant women has more than doubled upon the implementation of the iodine fortification program without an increase in preterm birth-rate.
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Authors | Sofie Bliddal, Malene Boas, Linda Hilsted, Lennart Friis-Hansen, Anders Juul, Torben Larsen, Ann Tabor, Jens Faber, Dorthe Hansen Precht, Ulla Feldt-Rasmussen |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 176
Issue 5
Pg. 603-612
(May 2017)
ISSN: 1479-683X [Electronic] England |
PMID | 28348022
(Publication Type: Journal Article)
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Copyright | © 2017 European Society of Endocrinology. |
Chemical References |
- Autoantibodies
- anti-thyroglobulin
- thyroid microsomal antibodies
- Thyroglobulin
- Iodine
- Iodide Peroxidase
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Topics |
- Adult
- Autoantibodies
(blood)
- Autoimmune Diseases
(complications, epidemiology)
- Cohort Studies
- Denmark
(epidemiology)
- Female
- Food, Fortified
- Humans
- Iodide Peroxidase
(immunology)
- Iodine
(administration & dosage)
- Longitudinal Studies
- Pregnancy
- Pregnancy Complications
(immunology)
- Premature Birth
(epidemiology)
- Prospective Studies
- Thyroglobulin
(immunology)
- Thyroid Diseases
(immunology)
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