Abstract | PURPOSE: METHODS:
Caveolin-1 expression was evaluated by immunochemistry on a tissue microarray from 424 patients treated with RC for UCB at a single institution. Caveolin-1 was considered overexpressed when at least 50% of the tumor cells stained positively. Univariable and multivariable Cox proportional hazards regression models were used to assess the association of Caveolin-1 expression with RFS, OS, and CSS. RESULTS: Overexpression of Caveolin-1 was observed in 116 (27.4%) patients and was associated with lymph node metastasis (P = 0.003). Median follow-up for patients alive at last follow-up was 129 months (interquartile range [IQR]: 82-178). Patients with overexpression of Caveolin-1 had significant worse RFS, OS, and CSS compared to those with normal expression (log-rank test, P = 0.008, P = 0.001, and P = 0.005, respectively). At multivariable analyses that adjusted for the effects of standard clinicopathologic features, Caveolin-1 remained associated with OS (hazard ratio = 1.47, P = 0.002) and CSS (hazard ratio = 1.42, P = 0.03). Conversely, no association with RFS was found (P = 0.1). Addition of Caveolin-1 in a model for prediction of survival did not improve the accuracy of the prognostic model. Actually, C-index did not differ among models with or without Caveolin-1 (0.72 for a model predicting RFS, 0.65 for OS, and 0.71 for CSS). CONCLUSIONS:
Caveolin-1 is overexpressed in one-third of patients with BCa treated with RC. Overexpression of Caveolin-1 is significantly associated with OS and CSS, but not with RFS, in patients with BCa treated with RC. However, it is not clinically useful as it does not improve upon the predictive accuracy of survival achieved by pathologic variables alone.
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Authors | Francesco Soria, Ilaria Lucca, Marco Moschini, Romain Mathieu, Morgan Rouprêt, Pierre I Karakiewicz, Alberto Briganti, Michael Rink, Kilian M Gust, Melanie R Hassler, Beat Foerster, Mohammad Abufarraj, Andrea Haitel, Tobias Klatte, Shahrokh F Shariat |
Journal | Urologic oncology
(Urol Oncol)
Vol. 35
Issue 6
Pg. 356-362
(06 2017)
ISSN: 1873-2496 [Electronic] United States |
PMID | 28342660
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Caveolin 1
(metabolism)
- Cystectomy
(methods)
- Female
- Humans
- Male
- Middle Aged
- Prognosis
- Recurrence
- Treatment Outcome
- Urinary Bladder Neoplasms
(immunology, pathology, surgery)
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