Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks.

Abstract

BACKGROUND:

We identified rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C gene polymorphisms of SERPINB5 (mammary serine protease inhibitor) that are specific to patients with oral cancer susceptibility and their clinicopathological status.

METHODOLOGY/PRINCIPAL FINDINGS:

In total, 1342 participants, including 601 healthy controls and 741 patients with oral cancer, were recruited for this study. Allelic discrimination of rs17071138 T/C, rs3744941 C/T, and rs8089104 T/C of the SERPINB5 gene was assessed by a real-time PCR with a TaqMan assay. We found that individuals carrying the polymorphic rs17071138 and rs8089104 are more susceptible to oral cancer (OR, 1.57; 95% CI, 1.07~2.31 and OR, 1.58; 95% CI, 1.04~2.39, respectively). Among oral cancer-related risk factor exposures, the individuals carrying the polymorphic rs17071138 had 4.26- (95% CI: 1.65~11.01; p = 0.002), 2.34- (95% CI: 1.19~4.61; p = 0.01), and 2.34-fold (95% CI: 1.38~3.96; p = 0.001) higher risks of developing oral cancer.

CONCLUSIONS:

Heterozygous TC of the SERPINB5 rs17071138 polymorphism may be a factor that increases susceptibility to oral cancer. Interactions of gene-to-gene and gene-to-oral cancer-related environmental risk factors have a synergetic effect that can further enhance oral cancer development.

• Authors: Hsiu-Ting Tsai, Ming-Ju Hsieh, Chiao-Wen Lin, Shih-Chi Su, Nae-Fang Miao, Shun-Fa Yang, Hui-Chuan Huang, Fu-Chih Lai, Yu-Fan Liu
• Journal: PloS one (PLoS One) Vol. 12 Issue 3 Pg. e0163369 ( 2017) ISSN: 1932-6203 [Electronic] United States
• PMID: 28339463 (Publication Type: Journal Article)

Chemical References

• SERPIN-B5
• Serpins

Topics

• Alcohol Drinking (adverse effects)
• Alleles
• Areca (adverse effects)
• Case-Control Studies
• Gene Frequency
• Gene-Environment Interaction
• Genetic Predisposition to Disease
• Humans
• Mouth Neoplasms (etiology, genetics)
• Polymorphism, Single Nucleotide
• Risk Factors
• Serpins (genetics)
• Smoking (adverse effects)