Abstract | BACKGROUND: STUDY DESIGN AND METHODS: The aim of this observational cohort study was to investigate the prevalence of depression and cognitive deficits in 104 patients having survived acute TTP. TTP survivors were repeatedly assessed by means of different standardized questionnaires to evaluate depression (IDS-SR) and mental performance (FLei). We received answers of 104 individual TTP patients and 55 of them participated in both surveys. RESULTS: Seventy-one of the 104 responding TTP patients (68%) suffered from depression and the severity of depression was similar in both surveys performed 1 year apart. Furthermore, TTP patients had considerably lower cognitive performance than controls. There was no correlation between prevalence of depression and cognitive deficits and the number and the severity of acute episodes. Impairment of mental performance correlated with the severity of depression (rs = 0.779). CONCLUSION: The prevalence of depression and cognitive deficits was significantly higher in TTP patients. Cognitive impairment seemed to be a consequence of depression, almost independently of number and severity of TTP episodes.
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Authors | Tanja Falter, Veronique Schmitt, Stephanie Herold, Veronika Weyer, Charis von Auer, Stefanie Wagner, Gudrun Hefner, Manfred Beutel, Karl Lackner, Bernhard Lämmle, Inge Scharrer |
Journal | Transfusion
(Transfusion)
Vol. 57
Issue 5
Pg. 1152-1162
(May 2017)
ISSN: 1537-2995 [Electronic] United States |
PMID | 28337761
(Publication Type: Journal Article, Observational Study)
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Copyright | © 2017 AABB. |
Topics |
- Acute Disease
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Cognitive Dysfunction
(etiology)
- Cohort Studies
- Depression
(etiology)
- Female
- Humans
- Male
- Middle Aged
- Prevalence
- Purpura, Thrombotic Thrombocytopenic
(complications)
- Recurrence
- Surveys and Questionnaires
- Time Factors
- Young Adult
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