Abstract | Background: The most popular screening test for primary aldosteronism is the plasma aldosterone/ renin ratio (ARR). Medications, dietary sodium, posture, and time of day all affect renin and aldosterone levels and can result in false-negative or false-positive ARRs if not controlled. Most antihypertensive medications affect the ARR and can interfere with interpretation of results. To our knowledge, no study has been undertaken to evaluate the effects of moxonidine on the ARR. Methods: Results: Compared with baseline, despite the expected significant falls in both systolic and diastolic blood pressure, levels of plasma aldosterone [median, 134 (range, 90 to 535) pmol/L], DRC [20 (10 to 37) mU/L], PRA [2.2 (1.0-3.8) ng/mL/h], and ARR using either DRC [8.0 (4.4 to 14.4)] or PRA [73 (36 to 218)] were not significantly changed after either 1 [135 (98-550) pmol/L, 20 (11-35) mU/L, 2.0 (1.2-4.1) ng/mL/h, 8.8 (4.2 to 15.9), and 73 (32-194), respectively] or 6 weeks [130 (90-500) pmol/L, 22 (8 to 40) mU/L, 2.1 (1.0 to 3.2) ng/mL/h, 7.7 (4.3 to 22.4), and 84 (32 to 192), respectively] of moxonidine. There were no changes in any urinary measurements. Conclusion:
Moxonidine was associated with no significant change in the ARR and may therefore be a good option for maintaining control of hypertension when screening for primary aldosteronism.
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Authors | Ashraf H Ahmed, Richard D Gordon, Gregory Ward, Martin Wolley, Brett C McWhinney, Jacobus P Ungerer, Michael Stowasser |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 102
Issue 6
Pg. 2039-2043
(06 01 2017)
ISSN: 1945-7197 [Electronic] United States |
PMID | 28324033
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Endocrine Society |
Chemical References |
- Antihypertensive Agents
- Imidazoles
- Aldosterone
- Sodium
- Creatinine
- moxonidine
- Renin
- Potassium
- Hydrocortisone
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Topics |
- Adult
- Aldosterone
(metabolism)
- Antihypertensive Agents
(pharmacology)
- Blood Pressure
(drug effects)
- Chromatography, High Pressure Liquid
- Creatinine
(metabolism)
- Healthy Volunteers
- Humans
- Hydrocortisone
(metabolism)
- Imidazoles
(pharmacology)
- Male
- Potassium
(metabolism)
- Renin
(drug effects, metabolism)
- Sodium
(metabolism)
- Tandem Mass Spectrometry
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