In Vitro Activities and Spectrum of the Novel Fluoroquinolone Lascufloxacin (KRP-AM1977).

Abstract

Lascufloxacin exhibited a broad spectrum of activity against various clinical isolates. Furthermore, lascufloxacin showed the most potent activity against Gram-positive bacteria among the quinolones tested and incomplete cross-resistance against existing quinolone-resistant strains. Enzymatic analysis indicated that lascufloxacin had potent inhibitory activity against both wild-type and mutated target enzymes. These results suggest that lascufloxacin may be useful in treating infections caused by various pathogens, including quinolone-resistant strains.

• Authors: Ryuta Kishii, Yuko Yamaguchi, Masaya Takei
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 61 Issue 6 (06 2017) ISSN: 1098-6596 [Electronic] United States
• PMID: 28320717 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 American Society for Microbiology.

Chemical References

• Anti-Bacterial Agents
• Fluoroquinolones
• lascufloxacin

Topics

• Anti-Bacterial Agents (pharmacology)
• Drug Resistance, Bacterial
• Escherichia coli (drug effects, isolation & purification)
• Fluoroquinolones (pharmacology)
• Humans
• Microbial Sensitivity Tests
• Staphylococcus aureus (drug effects, isolation & purification)
• Streptococcus pneumoniae (drug effects, isolation & purification)