Abstract | OBJECTIVE: To determine the effects of IV acetaminophen on core body temperature, blood pressure, and heart rate in febrile critically ill patients. DESIGN: Randomized, double-blind, placebo-controlled clinical trial. SETTING: Three adult ICUs at a large, urban, academic medical center. PATIENTS: INTERVENTION: An infusion of acetaminophen 1 g or saline placebo over 15 minutes. MEASUREMENT AND MAIN RESULTS: Core temperature and vital signs were measured at baseline and at 5-15-minute intervals for 4 hours after infusion of study drug. The primary outcome was time-weighted average core temperature adjusted for baseline temperature. Secondary outcomes included adjusted time-weighted average heart rate, blood pressure, and respiratory rate, along with changes-over-time for each. Baseline patient characteristics were similar in those given acetaminophen and placebo. Patients given acetaminophen had an adjusted time-weighted average temperature that was 0.47°C less than those given placebo (95% CI, -0.76 to -0.18; p = 0.002). The acetaminophen group had significantly lower adjusted time-weighted average systolic blood pressure (-17 mm Hg; 95% CI, -25 to -8; p < 0.001), mean arterial pressure (-7 mm Hg; 95% CI, -12 to -1; p = 0.02), and heart rate (-6 beats/min; 95% CI, -10 to -1; p = 0.03). Changes-over-time temperature, blood pressure, and heart rate outcomes were also significantly lower at 2 hours, but not at 4 hours. CONCLUSIONS:
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Authors | Hildy M Schell-Chaple, Kathleen D Liu, Michael A Matthay, Daniel I Sessler, Kathleen A Puntillo |
Journal | Critical care medicine
(Crit Care Med)
Vol. 45
Issue 7
Pg. 1199-1207
(Jul 2017)
ISSN: 1530-0293 [Electronic] United States |
PMID | 28319467
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Acetaminophen
(administration & dosage, therapeutic use)
- Adult
- Aged
- Blood Pressure
(drug effects)
- Body Temperature
(drug effects)
- Critical Illness
(therapy)
- Double-Blind Method
- Female
- Fever
(drug therapy)
- Heart Rate
(drug effects)
- Humans
- Infusions, Intravenous
- Intensive Care Units
- Male
- Middle Aged
- Respiratory Rate
(drug effects)
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