PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides.

Abstract

In most eukaryotes, phosphoinositides (PIs) have crucial roles in multiple cellular functions. Although the cellular levels of phosphatidylinositol 5-phosphate (PI5P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) are extremely low relative to some other PIs, emerging evidence demonstrates that both lipids are crucial for the endocytic pathway, intracellular signaling, and adaptation to stress. Mutations that causes defects in the biosynthesis of PI5P and PI(3,5)P2 are linked to human diseases including neurodegenerative disorders. Here, we review recent findings on cellular roles of PI5P and PI(3,5)P2, as well as the pathophysiological importance of these lipids.Key words: Phosphoinositides, Membrane trafficking, Endocytosis, Vacuoles/Lysosomes, Fab1/PIKfyve.

• Authors: Junya Hasegawa, Bethany S Strunk, Lois S Weisman
• Journal: Cell structure and function (Cell Struct Funct) Vol. 42 Issue 1 Pg. 49-60 (May 03 2017) ISSN: 1347-3700 [Electronic] Japan
• PMID: 28302928 (Publication Type: Journal Article, Review)

Chemical References

• Phosphatidylinositol Phosphates
• phosphatidylinositol 3,5-diphosphate
• phosphatidylinositol 5-phosphate

Topics

• Animals
• Disease
• Humans
• Intracellular Space (metabolism)
• Oxidative Stress
• Phosphatidylinositol Phosphates (metabolism)