Polyvalent 2D Entry Inhibitors for Pseudorabies and African Swine Fever Virus.

Abstract

African swine fever virus (ASFV) is one of the most dangerous viruses for pigs and is endemic in Africa but recently also spread into the Russian Federation and the Eastern border of the EU. So far there is no vaccine or antiviral drug available to curtail the infection. Thus, control strategies based on novel inhibitors are urgently needed. Another highly relevant virus infection in pigs is Aujeszky's disease caused by the alphaherpesvirus pseudorabies virus (PrV). This article reports the synthesis and biological evaluation of novel extracellular matrix-inspired entry inhibitors based on polyglycerol sulfate-functionalized graphene sheets. The developed 2D architectures bind enveloped viruses during the adhesion process and thereby exhibit strong inhibitory effects, which are equal or better than the common standards enrofloxacin and heparin as demonstrated for ASFV and PrV. Overall, the developed polyvalent 2D entry inhibitors are nontoxic and efficient nanoarchitectures, which interact with various types of enveloped viruses. Therefore they prevent viral adhesion to the host cell and especially target viruses that rely on a heparan sulfate-dependent cell entry mechanism.

• Authors: Benjamin Ziem, Jessica Rahn, Ievgen Donskyi, Kim Silberreis, Luis Cuellar, Jens Dernedde, Günther Keil, Thomas C Mettenleiter, Rainer Haag
• Journal: Macromolecular bioscience (Macromol Biosci) Vol. 17 Issue 6 (06 2017) ISSN: 1616-5195 [Electronic] Germany
• PMID: 28296132 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antiviral Agents
• Polymers
• polyglycerol
• Graphite
• Glycerol

Topics

• African Swine Fever (drug therapy, virology)
• African Swine Fever Virus (drug effects, pathogenicity)
• Animals
• Antiviral Agents (chemical synthesis, therapeutic use)
• Glycerol (chemistry, therapeutic use)
• Graphite (chemistry, therapeutic use)
• Herpesvirus 1, Suid (drug effects, pathogenicity)
• Humans
• Polymers (chemistry, therapeutic use)
• Pseudorabies (drug therapy, virology)
• Swine
• Virus Internalization (drug effects)