Abstract | INTRODUCTION:
Metabolic surgery is known to impact glucose tolerance but the exact mechanism is still unclear. Based on recently-published data, especially the role of the hindgut may require redefinition. METHODS: Either a loop duodeno- jejunostomy (DJOS) with exclusion of one third of total intestinal length, a loop duodeno- ileostomy (DiOS, exclusion of two thirds), or SHAM operation was performed in 9-week-old Zucker diabetic fatty rats. One, 3, and 6 months after surgery, an oral glucose tolerance test (OGTT) and glucose-stimulated hormone analyses were conducted. Body weight was documented weekly. RESULTS: DJOS and DiOS animals showed significantly better glucose control in all OGTTs than the SHAM group (two-way ANOVA p < 0.0001). Body weight developed largely parallel in both intervention groups; SHAM animals had gained significantly less weight after 6 months (Mann-Whitney DJOS/DiOS vs. SHAM p < 0.05, DJOS vs. DiOS p > 0.05). Operative interventions had no impact on GLP-1 and GIP levels at any time point (Mann-Whitney p > 0.05 for all). DJOS/DiOS operations could preserve insulin production up to 6 months, while there was already a sharp decline of insulin levels in the SHAM group (Mann-Whitney: DJOS/DiOS vs. SHAM p < 0.05 for all time points). Additionally, insulin sensitivity was improved significantly 1 month postoperative in both intervention groups compared to SHAM (Mann-Whitney DJOS/DiOS vs. SHAM p < 0.05). CONCLUSION: The data of the current study demonstrate a sharp amelioration of glucose control after duodenal exclusion with unchanged levels of GLP-1 and GIP. Direct or delayed hindgut stimulation had no impact on glucose control in our model.
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Authors | Claudia Laessle, Sven Michelmichel, Goran Marjanovic, Simon Kuesters, Gabriel Seifert, Ulrich T Hopt, Jodok Matthias Fink |
Journal | Obesity surgery
(Obes Surg)
Vol. 27
Issue 8
Pg. 2090-2098
(08 2017)
ISSN: 1708-0428 [Electronic] United States |
PMID | 28281233
(Publication Type: Journal Article)
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Topics |
- Animals
- Diabetes Mellitus, Experimental
(complications, surgery)
- Diabetes Mellitus, Type 2
(complications, surgery)
- Duodenum
(surgery)
- Enterostomy
(adverse effects, methods)
- Gastric Bypass
(adverse effects, methods)
- Glucose Tolerance Test
- Insulin Resistance
- Intestines
(pathology, surgery)
- Male
- Obesity, Morbid
(complications, pathology, surgery)
- Organ Size
(physiology)
- Rats
- Rats, Zucker
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