Abstract | BACKGROUND:
Adult T-cell leukemia/lymphoma is a peripheral disease associated with human T-cell lymphotropic virus type 1. Treatment is carried out according to clinical type with watchful waiting being recommended for less aggressive types. Aggressive adult T-cell leukemia/lymphoma is generally treated with chemotherapy and/or antivirals. The objective of this study was to correlate the survival of patients diagnosed in Bahia, Brazil, with the therapeutic approaches employed and to evaluate what issues existed in their treatment processes. METHODS: RESULTS: Complete response was achieved in seven smoldering patients with symptomatic treatment, in two with chronic disease using antivirals/ chemotherapy, in one with acute disease using antivirals and in one lymphoma using the LSG15 regimen [ vincristine, cyclophosphamide, doxorubicin, and prednisolone (VCAP); doxorubicin, ranimustine, and prednisolone ( AMP); and vindesine, etoposide, carboplatin, and prednisolone (VECP)]. Smoldering patients who received symptomatic treatment presented longer survival. Favorable chronic patients treated with antivirals presented longer survival compared to the unfavorable subtype. However, for the acute form, first-line chemotherapy was better, albeit without significance, than antivirals. Only one of the patients with lymphoma and primary cutaneous tumors responded. CONCLUSIONS:
|
Authors | Pedro Dantas Oliveira, Ítala Gomes, Victor Hugo Gomes Souza, Ernesto Cunha Pires, Glória Bomfim Arruda, Achiléa Bittencourt |
Journal | Revista brasileira de hematologia e hemoterapia
(Rev Bras Hematol Hemoter)
2017 Jan - Mar
Vol. 39
Issue 1
Pg. 13-19
ISSN: 1516-8484 [Print] Brazil |
PMID | 28270340
(Publication Type: Journal Article)
|
Copyright | Copyright © 2016 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved. |