Abstract |
In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs. This was also the case for T cell acute lymphoblastic leukemia, which is a malignant blood disorder arising from oncogenic events during normal T cell development in the thymus. By studying the transcriptomic profile of protein-coding genes, several oncogenic events leading to T cell acute lymphoblastic leukemia ( T-ALL) could be identified. In recent years, it became apparent that several of these oncogenes function via microRNAs and long noncoding RNAs. In this review, we give a detailed overview of the studies that describe the noncoding RNAome in T-ALL oncogenesis and normal T cell development.
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Authors | Annelynn Wallaert, Kaat Durinck, Tom Taghon, Pieter Van Vlierberghe, Frank Speleman |
Journal | Journal of hematology & oncology
(J Hematol Oncol)
Vol. 10
Issue 1
Pg. 66
(03 07 2017)
ISSN: 1756-8722 [Electronic] England |
PMID | 28270163
(Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Carcinogenesis
(genetics)
- Humans
- Lymphopoiesis
(genetics)
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
(genetics)
- RNA, Untranslated
(analysis, physiology)
- Thymocytes
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