Prognostic value of the C-reactive protein/albumin ratio in patients with laryngeal squamous cell carcinoma.

Abstract

PURPOSE:

The present study was designed to retrospectively evaluate the prognostic value of the C-reactive protein/albumin (CRP/ALB) ratio in laryngeal squamous cell carcinoma (LSCC).

METHODS:

One hundred and twenty-nine newly diagnosed LSCC patients admitted between May 2006 and October 2011 were retrospectively reviewed. Their serum CRP and ALB were quantified preoperatively. The relationship between the CRP/ALB ratio and the clinicopathologic features was analyzed. Receiver operating characteristic curve was used to calculate the prognostic value of the CRP/ALB ratio. Then, the Cox proportional hazards model was used in univariate and multivariate analyses to identify significant prognostic factors associated with disease-free survival and overall survival.

RESULTS:

The cutoff value for CRP/ALB ratio was 0.047. An elevated CRP/ALB ratio was significantly associated with nodal metastasis, late disease stage, and recurrence. Also, high values of CRP/ALB ratio were significant predictors for poor overall survival and disease-free survival on multivariate analysis.

CONCLUSION:

Pretreatment CRP/ALB ratio may be a significant prognostic marker in LSCC.

• Authors: Shi-Tong Yu, Zhiwei Zhou, Qian Cai, Faya Liang, Ping Han, Renhui Chen, Xiao-Ming Huang
• Journal: OncoTargets and therapy (Onco Targets Ther) Vol. 10 Pg. 879-884 ( 2017) ISSN: 1178-6930 [Print] New Zealand
• PMID: 28243123 (Publication Type: Journal Article)