Accumulation of immunoglobulin G against Dermatophagoides farinae tropomyosin in dorsal root ganglia of NC/Nga mice with atopic dermatitis-like symptoms.
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| Abstract |
Atopic dermatitis (AD), a chronic inflammatory skin disease, manifests as intractable itch, but its underlying mechanisms are poorly understood. This study assessed the relationship between immunoglobulin G (IgG) and dorsal root ganglia (DRG) in NC/Nga mice, a model of AD that manifests AD-like symptoms including itch. Immunohistochemical analysis showed large amounts of IgG in DRG extracts of NC/Nga mice with AD-like dermatitis, with a large fraction of the IgG distributed in satellite glial cells of the DRG. Proteomic analysis showed that this IgG was reactive against tropomyosin of Dermatophagoides farinae. These findings indicate that the accumulation of anti-tropomyosin IgG in DRG of atopic NC/Nga mice may be associated with the pathogenesis of AD-like symptoms, including itch.
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| Authors | Ayaka Otsu, Hiroaki Kawasaki, Mitsutoshi Tominaga, Ayako Shigenaga, Hironori Matsuda, Nobuaki Takahashi, Tadaaki Nakajima, Hisashi Naito, Takeshi Baba, Hideoki Ogawa, Yasuhiro Tomooka, Fumiyuki Yamakura, Kenji Takamori |
| Journal | Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 485 Issue 4 Pg. 707-712 (Apr 15 2017) ISSN: 1090-2104 [Electronic] United States |
| PMID | 28237704 (Publication Type: Journal Article) |
| Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
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