Cannabidiol: State of the art and new challenges for therapeutic applications.

Abstract

Over the past years, several lines of evidence support a therapeutic potential of Cannabis derivatives and in particular phytocannabinoids. Δ9-THC and cannabidiol (CBD) are the most abundant phytocannabinoids in Cannabis plants and therapeutic application for both compounds have been suggested. However, CBD is recently emerging as a therapeutic agent in numerous pathological conditions since devoid of the psychoactive side effects exhibited instead by Δ9-THC. In this review, we highlight the pharmacological activities of CBD, its cannabinoid receptor-dependent and -independent action, its biological effects focusing on immunomodulation, angiogenetic properties, and modulation of neuronal and cardiovascular function. Furthermore, the therapeutic potential of cannabidiol is also highlighted, in particular in nuerological diseases and cancer.

• Authors: Simona Pisanti, Anna Maria Malfitano, Elena Ciaglia, Anna Lamberti, Roberta Ranieri, Gaia Cuomo, Mario Abate, Giorgio Faggiana, Maria Chiara Proto, Donatella Fiore, Chiara Laezza, Maurizio Bifulco
• Journal: Pharmacology & therapeutics (Pharmacol Ther) Vol. 175 Pg. 133-150 (Jul 2017) ISSN: 1879-016X [Electronic] England
• PMID: 28232276 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2017. Published by Elsevier Inc.

Chemical References

• Cannabidiol

Topics

• Animals
• Cannabidiol (pharmacology, therapeutic use)
• Humans
• Nervous System Diseases (drug therapy)