The effects of ACTH 1-17 on GH secretion in vitro.

Abstract

Recently we demonstrated that ACTH 1-17 infusion in normal subjects is able to stimulate growth hormone (GH) secretion. In order to study the mechanism by which ACTH 1-17 induces this hormonal secretory pattern, we examined the effects of ACTH 1-17 addition to primary cultures of rat anterior pituitary cells and of two human pituitary adenomas (a mixed GH- and PRL-secreting adenoma and a prolactinoma) on GH and PRL secretion. Normal rat pituitary cells responded to rGRF with a dose-dependent increase of rGH: ACTH 1-17 induced a slight not significant increase of rGH secretion even at micromolar concentrations. Furthermore no additive effect of ACTH 1-17 on rGRF-stimulated GH release was observed. No significant stimulatory effect was also documented in the human tumors studied. These results suggest that the GH releasing activity of ACTH 1-17 observed in vivo is mediated via a direct action on CNS.

• Authors: G P Ceda, L Denti, G Valenti
• Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (Horm Metab Res) Vol. 19 Issue 8 Pg. 361-3 (Aug 1987) ISSN: 0018-5043 [Print] Germany
• PMID: 2822561 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Peptide Fragments
• Adrenocorticotropic Hormone
• Prolactin
• Growth Hormone
• Growth Hormone-Releasing Hormone
• ACTH (1-17)

Topics

• Adenoma (metabolism)
• Adrenocorticotropic Hormone (pharmacology)
• Animals
• Cells, Cultured
• Female
• Growth Hormone (metabolism)
• Growth Hormone-Releasing Hormone (pharmacology)
• Humans
• Male
• Peptide Fragments (pharmacology)
• Pituitary Gland, Anterior (cytology, drug effects, metabolism)
• Pituitary Neoplasms (metabolism)
• Prolactin (metabolism)
• Rats
• Rats, Inbred Strains