Abstract | OBJECTIVE: METHODS: 450 PTC patients who received total thyroidectomy with central neck dissection(CND) combined with modified radical lateral neck dissection(LND) were divided into two groups: with or without skip metastases. The clinicopathological characteristics were statistically compared and analyzed, and univariate and multivariate analyses were performed to detect the risk factors of skip metastasis. RESULTS: The skip metastasis rate was 8.7% (39/450), and patients with skip metastases had fewer lateral lymph node metastases but were more likely to have single-level lateral metastasis, which are considered Level II(P<0.05). Skip metastasis was significantly associated with the primary tumor location in the upper portion (OR=18.495, 95% CI 6.612-51.731), a primary tumor size ≤10mm (OR=32.492, 95% CI 11.973-88.174) and Capsule invasion (OR=5.822, 95% CI 1.954-17.343) as demonstrated by our prospective study of 10 patients who received an injection of 0.1 ml carbon nanoparticles under ultrasonography in the upper portion of the lobe: 7(70%) had lateral compartment lymph node black staining without ipsilateral center compartment lymph node staining. However, skip metastasis did not affect the PTC patients' long-term tumor-free survival rate (P=0.432). CONCLUSION: Skip metastases can be common, and the primary tumor location in the upper portion, a primary tumor size ≤10 mm, and capsular invasion are closely linked to skip metastasis. The lateral compartment should be carefully evaluated.
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Authors | Jianyong Lei, Jinjing Zhong, Ke Jiang, Zhihui Li, Rixiang Gong, Jingqiang Zhu |
Journal | Oncotarget
(Oncotarget)
Vol. 8
Issue 16
Pg. 27022-27033
(Apr 18 2017)
ISSN: 1949-2553 [Electronic] United States |
PMID | 28223546
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Biomarkers
- Carcinoma, Papillary
(diagnosis, mortality, pathology, surgery)
- Female
- Humans
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
- Male
- Middle Aged
- Neck Dissection
- Odds Ratio
- Prognosis
- ROC Curve
- Skin Neoplasms
(diagnosis, secondary)
- Thyroid Cancer, Papillary
- Thyroid Neoplasms
(diagnosis, mortality, pathology, surgery)
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