The less traumatic use of surgical adhesives rather than
sutures for mesh fixation in
hernia repair has started to gain popularity because they induce less host tissue damage and provoke less
postoperative pain. This study examines the host tissue response to a new
cyanoacrylate (CA) adhesive (n-octyl, OCA). Partial defects (3 × 5 cm) created in the rabbit anterior abdominal wall were repaired by mesh fixation using OCA, Glubran2®(n-butyl-CA), Ifabond®(n-hexyl-CA) or
sutures. Samples were obtained at 14/90 days for morphology,
collagens qRT-PCR/immunofluorescence and biomechanical studies. All meshes were successfully fixed.
Seroma was detected mainly in the
Glubran group at 14 days. Meshes fixed using all methods showed good host tissue incorporation. No signs of degradation of any of the adhesives were observed. At 14 days,
collagen 1 and 3
mRNA expression levels were greater in the
suture and OCA groups, and lower in
Ifabond, with levels varying significantly in the latter group with respect to the others. By 90 days, expression levels had fallen in all groups, except for
collagen 3
mRNA in
Ifabond.
Collagen I and III
protein expression was marked in the
suture and OCA groups at 90 days, but lower in
Ifabond at both time points. Tensile strengths were similar across groups. Our findings indicate the similar behavior of the adhesives to
sutures in terms of good tissue incorporation of the meshes and optimal repair zone strength. The lower
seroma rate and similar collagenization to controls induced by OCA suggests its improved behavior over the other two
glues. This article deals with a preclinical study to examine different aspects of the repair process in the host of three alkyl
cyanoacrylates (n-butyl (
GLUBRAN 2), n-hexyl (
IFABOND), and
n-octyl cyanoacrylate (EVOBOND)) compared to
sutures (control), in the fixation of
surgical meshes for
hernia repair. It goes into detail about
collagen deposition in the repair zone at short and medium term. The results obtained demonstrate lower
seroma rate and similar collagenization to
sutures induced by the n-octyl suggesting better behavior than the other two
cyanoacrylates.