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Multiple Myeloma, Version 3.2017, NCCN Clinical Practice Guidelines in Oncology.

Abstract
Multiple myeloma (MM) is caused by the neoplastic proliferation of plasma cells. These neoplastic plasma cells proliferate and produce monoclonal immunoglobulin in the bone marrow causing skeletal damage, a hallmark of multiple myeloma. Other MM-related complications include hypercalcemia, renal insufficiency, anemia, and infections. The NCCN Multiple Myeloma Panel members have developed guidelines for the management of patients with various plasma cell dyscrasias, including solitary plasmacytoma, smoldering myeloma, multiple myeloma, systemic light chain amyloidosis, and Waldenström's macroglobulinemia. The recommendations specific to the diagnosis and treatment of patients with newly diagnosed MM are discussed in this article.
AuthorsShaji K Kumar, Natalie S Callander, Melissa Alsina, Djordje Atanackovic, J Sybil Biermann, Jason C Chandler, Caitlin Costello, Matthew Faiman, Henry C Fung, Cristina Gasparetto, Kelly Godby, Craig Hofmeister, Leona Holmberg, Sarah Holstein, Carol Ann Huff, Adetola Kassim, Michaela Liedtke, Thomas Martin, James Omel, Noopur Raje, Frederic J Reu, Seema Singhal, George Somlo, Keith Stockerl-Goldstein, Steven P Treon, Donna Weber, Joachim Yahalom, Dorothy A Shead, Rashmi Kumar
JournalJournal of the National Comprehensive Cancer Network : JNCCN (J Natl Compr Canc Netw) Vol. 15 Issue 2 Pg. 230-269 (02 2017) ISSN: 1540-1413 [Electronic] United States
PMID28188192 (Publication Type: Journal Article, Practice Guideline)
CopyrightCopyright © 2017 by the National Comprehensive Cancer Network.
Chemical References
  • Antineoplastic Agents
  • Immunoglobulins
  • Myeloma Proteins
  • multiple myeloma M-proteins
Topics
  • Antineoplastic Agents (supply & distribution, therapeutic use)
  • Antineoplastic Combined Chemotherapy Protocols (standards, therapeutic use)
  • Asymptomatic Diseases
  • Chemotherapy, Adjuvant (methods, standards)
  • Humans
  • Immunoglobulins (blood)
  • Magnetic Resonance Imaging
  • Maintenance Chemotherapy (methods, standards)
  • Medical Oncology (standards)
  • Multiple Myeloma (blood, diagnosis, therapy)
  • Myeloma Proteins (analysis)
  • Positron Emission Tomography Computed Tomography
  • Radiotherapy, Adjuvant (methods, standards)
  • Serologic Tests
  • Standard of Care
  • Stem Cell Transplantation (methods, standards)
  • Treatment Outcome

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