Abstract | BACKGROUND: CASE: We present a case of an 84-year-old man who was admitted to the hospital for progression of dyspnea. Basic laboratory tests showed a serum concentration of conjugated bilirubin, measured using the diazo spectrophotometric method, which was much higher than that of total bilirubin. The cause of the discrepancy was attributed to analytical interference by monoclonal immunoglobulins, which helped establish a diagnosis of lymphoproliferative disorder. CONCLUSION: Monoclonal immunoglobulins are relatively rare in serum but are an important cause of analytical interference. Monoclonal immunoglobulins should always be considered a source of interference when unexpectedly high, low, or contradictory data are encountered, and appropriate confirmatory tests (electrophoresis, imunofixation) should be performed in such circumstances. Failure to do so can result in errors in diagnosis and inadequate treatment. Conversely, when samples contain abnormal and especially high monoclonal immunoglobulin levels, the biochemical data should be carefully examined for any discrepancies, such as paraprotein interference, and the results should be taken into consideration in patient management.Key words: paraproteins - lymphoproliferative disorders - bilirubin - interferenceThe authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.Submitted: 22. 1. 2016Accepted: 1. 12. 2016.
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Authors | I Kurfürstová, T Šálek, E Kadlčková, M Pšenčík |
Journal | Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti
(Klin Onkol)
Winter 2017
Vol. 30
Issue 1
Pg. 55-57
ISSN: 0862-495X [Print] Czech Republic |
Vernacular Title | Analytická interference může vést k diagnostice lymfoproliferativního onemocnění. |
PMID | 28185466
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Aged, 80 and over
- Bilirubin
(blood)
- Humans
- Lymphoproliferative Disorders
(blood, diagnosis)
- Male
- Paraproteins
(metabolism)
- Spectrophotometry
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