Ferret model for acquired subglottic stenosis.

Abstract

Researchers continue to look for an improved animal model for the study of acquired subglottic stenosis. This report describes a ferret model that reliably produces 40% to 60% stenosis with a method analogous to the pathophysiology of prolonged endotracheal intubation. Unlike some previously developed animal models, this model has a low morbidity and a perioperative mortality of less than 5%. Ferrets are small, hardy animals that are inexpensive and easy to house, handle, and anesthetize. They are readily available from breeders in a uniform size, age, and sex. Their airway is disproportionately large for their body size, making them particularly well suited for the study of acquired subglottic stenosis and subsequent surgical therapy.

• Authors: K J Alexander, D E Schuller
• Journal: The Annals of otology, rhinology, and laryngology (Ann Otol Rhinol Laryngol) Vol. 98 Issue 11 Pg. 910-5 (Nov 1989) ISSN: 0003-4894 [Print] United States
• PMID: 2817685 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Topics

• Animals
• Carnivora
• Disease Models, Animal
• Ferrets
• Laryngostenosis (etiology, pathology)
• Larynx (pathology)