[Use of acetylcholinesterase reactivators and central cholinolytics in the treatment of experimental tetanus poisoning].

Abstract

Experiments were conducted on rabbits with tetanus intoxication induced by the intravenous injection of a lethal dose of the toxin; a study was made of the therapeutic efficacy of the acetylcholinesterase reactivators--dipyroxim and isonitrosine, and also of the central cholinolytics--amizyl and diphacyl. In dose of 25 mg/kg dipyroxim produced no therapeutic effect, and in doses of 30--40 mg/kg caused the animal death. Amizyl and diphacil in a dose of 3--4 mg/kg caused elimination of tonic convulsions for 1 1/2--2 hours. As to isonitrosin--it produced the same effect for 4--5 hours. In case of combined administration of reactivators and cholinolytics convulsions were eliminated for 4--5 hours.

• Authors: Ia I Aleksevich
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 86 Issue 7 Pg. 40-2 ( 1978) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Primenenie reaktivatorov atsetilkholinésterazy i tsentral'nykh kholinolitikov pri lechenii éksperimental'noĭ stolbniachnoĭ intoksikatsii.
• PMID: 28162 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Butanones
• Cholinesterase Reactivators
• Diphenylacetic Acids
• Parasympatholytics
• Trimedoxime
• Benactyzine
• Acetylcholinesterase

Topics

• Acetylcholinesterase (metabolism)
• Animals
• Benactyzine (therapeutic use)
• Butanones (therapeutic use)
• Cholinesterase Reactivators (therapeutic use)
• Diphenylacetic Acids (therapeutic use)
• Female
• Male
• Motor Cortex (enzymology)
• Motor Neurons (enzymology)
• Parasympatholytics (therapeutic use)
• Rabbits
• Spinal Cord (enzymology)
• Tetanus (drug therapy, enzymology)
• Trimedoxime (therapeutic use)