Lipidomics is a
lipid-targeted metabolomics approach aiming at comprehensive analysis of
lipids in biological systems. Recent technological progresses in mass spectrometry, nuclear magnetic resonance spectroscopy, and chromatography have significantly enhanced the developments and applications of metabolic profiling of
lipids in more complex biological samples. As many diseases reveal a notable change in
lipid profiles compared with that of healthy people, lipidomics have also been broadly introduced to scientific research on diseases. Exploration of
lipid biochemistry by lipidomics approach will not only provide insights into specific roles of
lipid molecular species in health and disease, but it will also support the identification of potential
biomarkers for establishing preventive or therapeutic approaches for human health. This chapter aims to illustrate how lipidomics can contribute for understanding the biological mechanisms inherent to
schizophrenia and why
lipids are relevant
biomarkers of
schizophrenia. The application of lipidomics in clinical studies has the potential to provide new insights into
lipid profiling and pathophysiological mechanisms underlying
schizophrenia. The future perspectives of lipidomics in
mental disorders are also discussed herein.