Abstract | BACKGROUND AND PURPOSE: METHODS: This single-center study retrospectively assessed 1792 non-cardioembolic ischemic stroke patients discharged from January 2013 to October 2014, and followed for 12months. Patients were categorized as current-smokers and never-smokers. Primary outcome was a composite of secondary ischemic stroke, myocardial infarction and all-cause death. Secondary outcome was secondary ischemic stroke. RESULTS: 1066 patients were current-smokers and 726 were never-smokers. Compared with never-smokers, current-smokers had significantly higher rates of ischemic stroke (4.3% vs. 1.2%; adjusted OR: 3.60, 95%CI: 1.50-8.64, p=0.004). Regarding the primary outcome, among smokers, rates showed a lower trend in clopidogrel vs. aspirin groups (3.7% vs. 6.4%; adjusted OR 0.57, 95%CI: 0.31-1.07, p=0.08), but no difference among never-smokers (2.1% vs. 1.0%; adjusted OR: 1.67, 95%CI: 0.47-5.89, p=0.42). Similarly, among smokers, trending lower rates for recurrent ischemic stroke were observed in clopidogrel vs. aspirin group (3.1% vs. 5.0%; adjusted OR: 0.60, 95%CI: 0.31-1.18, p=0.14); but no difference between the two groups among never-smokers (1.7% vs. 1.0%; adjusted OR 1.36, 95%CI: 0.36-5.52, p=0.65). CONCLUSIONS: Smoking is a major risk factor for recurrent stroke in our retrospective non-cardioembolic ischemic stroke cohort. Active-smokers trend toward better cardiovascular outcomes when on clopidogrel. This finding needs to be confirmed in a prospective cohort.
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Authors | Qian Zhang, Yuan Wang, Haiqing Song, Chengbei Hou, Qingyu Cao, Kai Dong, Xiaoqin Huang, Wuwei Feng, Bruce Ovbiagele, Moli Wang, Xunming Ji |
Journal | Journal of the neurological sciences
(J Neurol Sci)
Vol. 373
Pg. 41-44
(Feb 15 2017)
ISSN: 1878-5883 [Electronic] Netherlands |
PMID | 28131222
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2016. Published by Elsevier B.V. |
Chemical References |
- Platelet Aggregation Inhibitors
- Clopidogrel
- Ticlopidine
- Aspirin
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Topics |
- Aspirin
(therapeutic use)
- Brain Ischemia
(complications, drug therapy, mortality)
- Clopidogrel
- Female
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(complications, mortality)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Recurrence
- Retrospective Studies
- Smoking
(mortality)
- Stroke
(complications, drug therapy, mortality)
- Ticlopidine
(analogs & derivatives, therapeutic use)
- Treatment Outcome
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