Lead adsorption, anticoagulation and in vivo toxicity studies on the new magnetic nanomaterial Fe3O4@SiO2@DMSA as a hemoperfusion adsorbent.

Abstract

This project aimed to develop and characterize a new nanoadsorbent for hemoperfusion. Fe3O4 nanoparticles synthesized by a facile solvothermal method were coated with SiO2 and further modified by DMSA. TEM, XRD, FTIR, XPS and SEM were performed before and after lead adsorption to reveal the general performance and adsorption mechanism. Rabbit lead poisoning models were established to study the adsorption rate; then, a pig hemoperfusion experiment was used for further validation. In addition, coagulation, liver, kidney and heart function, blood lipids, electrolytes and the immune inflammatory system were studied before and after hemoperfusion. The results indicated that the materials had a high adsorption rate and chemisorbed lead mainly in the plasma. No obvious coagulation-fibrinolysis, organ toxicity, electrolyte disturbances, inflammatory reactions or immunosuppression was observed. The excellent blood compatibility and high biosafety of this material demonstrate its potential as a new type of hemoperfusion adsorbent.

• Authors: Yang Xiang, Zhiming Bai, Shufang Zhang, Yan Sun, Shunlan Wang, Xiaobin Wei, Wenshi Mo, Jiale Long, Zhenxiang Liu, Chao Yang, Linlin Zheng, Xueyi Guo, Wang Xiaoyang, Fangfang Mao, Ningchuan Feng
• Journal: Nanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 13 Issue 4 Pg. 1341-1351 (05 2017) ISSN: 1549-9642 [Electronic] United States
• PMID: 28115250 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Chemical References

• Lead
• Silicon Dioxide
• Succimer
• Ferrosoferric Oxide

Topics

• Adsorption
• Animals
• Ferrosoferric Oxide (chemistry)
• Hemoperfusion
• Lead (chemistry)
• Lead Poisoning (therapy)
• Materials Testing
• Nanoparticles (chemistry)
• Rabbits
• Silicon Dioxide (chemistry)
• Succimer (chemistry)
• Swine
• Toxicity Tests