A novel and effective delivery method for polyglycolic acid sheets to post-endoscopic submucosal dissection ulcers.

Abstract

Background and aims Shielding methods for post-endoscopic submucosal dissection (ESD) ulcers have delivery-related problems. We developed an enveloped device for this purpose and evaluated its usefulness. Materials and methods Polyglycolic acid (PGA) sheets were delivered to six 3.0-cm ulcers in two resected porcine stomachs and six 5.0-cm ulcers in another three stomachs. In the regular method group, small PGA sheets were delivered via forceps. In the novel method group, a large PGA sheet was delivered via the new device. The methods were compared in terms of time, and macroscopic and histological findings of the ulcer floor. Results The median time required to cover a 3.0-cm ulcer was 0.39 min/cm2 in the novel method group and 1.03 min/cm2 in the regular method group (P = 0.03), and to cover a 5.0-cm ulcer was 0.38 min/cm2 and 0.85 min/cm2, respectively (P = 0.03). In the novel method group, the PGA sheets were in close contact, fully covering the ulcer floor. In the regular method group, the sheets were partly elevated from the ulcer floor. Conclusions This novel technique seems promising in this preliminary study.

• Authors: Toshitatsu Takao, Yoshitaka Takegawa, Hiroyuki Ono, Madoka Takao, Shiro Oka, Noriko Shinya, Hiromu Kutsumi, Takeshi Azuma
• Journal: Endoscopy (Endoscopy) Vol. 49 Issue 4 Pg. 359-364 (Apr 2017) ISSN: 1438-8812 [Electronic] Germany
• PMID: 28103620 (Publication Type: Journal Article, Video-Audio Media)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Biocompatible Materials
• Polyglycolic Acid

Topics

• Animals
• Biocompatible Materials
• Endoscopic Mucosal Resection (adverse effects)
• Gastric Mucosa (surgery)
• Gastroscopy
• Operative Time
• Polyglycolic Acid
• Prosthesis Implantation (instrumentation, methods)
• Stomach Ulcer (etiology, pathology, therapy)
• Swine