Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: MAIN OUTCOME MEASURES: Medication possession ratio (MPR), discontinuation rate, and mean time to discontinuation were assessed post-index. Pairwise comparisons ( lurasidone versus each drug) were conducted using chi-square tests and Student's t-tests. RESULTS: There were 146 Medicaid (mean age 43.5 years, 47.9% female) and 63 commercial (mean age 40.0 years, 42.9% female) patients treated with lurasidone. In the Medicaid population, the MPR for patients treated with lurasidone was 0.60, versus 0.41-0.48 for patients treated with other antipsychotics (all p < .05). Patients treated with lurasidone exhibited a lower discontinuation rate compared to patients treated with all other antipsychotics (49.3% versus 62.3%-68.3%, all p < .05). The mean time to discontinuation with lurasidone was significantly longer than with ziprasidone (p < .05). In the commercial population, the MPR for patients treated with lurasidone (0.61) was higher compared to patients treated with quetiapine (0.44) and ziprasidone (0.43) (both p < .05). The discontinuation rate (44.4%) was lower for patients treated with lurasidone compared to patients treated with all other antipsychotics except risperidone (p < .05). The mean time to discontinuation was longer for lurasidone than with other antipsychotics. CONCLUSIONS: In Medicaid and commercial populations, patients treated with lurasidone demonstrated greater adherence compared to patients treated with other atypical antipsychotics. Limitations of using administrative claims data include potential errors or inconsistencies in coding, and lack of complete clinical information.
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Authors | Krithika Rajagopalan, Sally Wade, Nicole Meyer, Antony Loebel |
Journal | Current medical research and opinion
(Curr Med Res Opin)
Vol. 33
Issue 5
Pg. 813-820
(05 2017)
ISSN: 1473-4877 [Electronic] England |
PMID | 28098496
(Publication Type: Journal Article)
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Chemical References |
- Antipsychotic Agents
- Piperazines
- Thiazoles
- Benzodiazepines
- Quetiapine Fumarate
- ziprasidone
- Aripiprazole
- Risperidone
- Olanzapine
- Lurasidone Hydrochloride
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Topics |
- Adult
- Antipsychotic Agents
(economics, therapeutic use)
- Aripiprazole
(economics, therapeutic use)
- Benzodiazepines
(economics, therapeutic use)
- Female
- Humans
- Insurance Claim Review
- Lurasidone Hydrochloride
(economics, therapeutic use)
- Male
- Medicaid
(economics)
- Medication Adherence
(statistics & numerical data)
- Middle Aged
- Olanzapine
- Piperazines
(economics, therapeutic use)
- Quetiapine Fumarate
(economics, therapeutic use)
- Risperidone
(economics, therapeutic use)
- Schizophrenia
(drug therapy, economics)
- Thiazoles
(economics, therapeutic use)
- United States
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