MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors.

Abstract

BACKGROUND:

Elevated MYB expression has been documented in adenoid cystic carcinoma (ACC), cylindroma, and spiradenoma, but the specificity of this finding is unknown. CD117 and SOX-10 expression also occurs in some cutaneous adnexal tumors. This study assesses MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors.

METHODS:

Retrospective analysis of 184 benign adnexal tumors (140 eccrine/apocrine, 40 follicular and 10 sebaceous), and 30 malignant adnexal tumors was performed with MYB, SOX-10 and CD117 immunostaining.

RESULTS:

In the benign adnexal tumors, 16% (23/140) significantly expressed MYB. MYB expression was limited to cylindromas and to a lesser extent, spiradenomas in the benign cohort. Elevated MYB expression was detected in mucinous carcinoma, endocrine mucin-producing sweat gland carcinoma and 1 and 4 cases of extramammary Paget's disease (EMPD) in the malignant cohort. CD117 and SOX-10 had similar overall positivity rates in benign apocrine and eccrine tumors (45% and 68% respectively), and were generally negative in other benign and malignant adnexal tumors.

CONCLUSION:

Expression of MYB appears limited to a small number of cutaneous adnexal tumors, including cylindromas, spiradenomas, ACCs, mucinous carcinoma, endocrine mucin-producing sweat gland carcinoma and some cases of EMPD.

• Authors: Mara Therese P Evangelista, Jeffrey P North
• Journal: Journal of cutaneous pathology (J Cutan Pathol) Vol. 44 Issue 5 Pg. 444-450 (May 2017) ISSN: 1600-0560 [Electronic] United States
• PMID: 28098399 (Publication Type: Journal Article)
• Copyright: © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Proto-Oncogene Proteins c-myb
• SOX10 protein, human
• SOXE Transcription Factors
• Proto-Oncogene Proteins c-kit

Topics

• Adnexal Diseases (metabolism, pathology)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Proto-Oncogene Proteins c-kit (biosynthesis)
• Proto-Oncogene Proteins c-myb (biosynthesis)
• Retrospective Studies
• SOXE Transcription Factors (biosynthesis)
• Skin Neoplasms (metabolism, pathology)