Pretreatment with 5-Fluorouracil Cream Enhances the Efficacy of Daylight-mediated Photodynamic Therapy for Actinic Keratosis.

Abstract	The efficacy of photodynamic therapy (PDT) with methyl aminolevulinate is reduced when treating actinic keratosis (AK) on the extremities in comparison with the face and scalp. Studies indicate that PDT efficacy can be improved by combining PDT with other treatment modalities. This randomized intra-individual study investigated whether pretreatment with topical 5% 5-fluorouracil (5-FU) enhanced the treatment efficacy of daylight-mediated PDT in 24 patients with AKs on the hands. One hand of each patient was given 7 days of pretreatment with 5-FU twice daily before daylight-PDT, whereas the other hand was treated with daylight-PDT alone. At 3-month follow-up the overall lesion response rate was significantly higher for the combination of 5-FU and daylight-PDT (62.7%) than for daylight-PDT alone (51.8%) (p = 0.001). Furthermore, pain and erythema in relation to treatment were similar in the 2 groups (p = 1.0 and p = 0.2, respectively). Combination therapy is a safe and effective method to improve daylight-PDT for acral AKs.
Authors	Christoffer V Nissen, Ida Marie Heerfordt, Stine R Wiegell, Carsten S Mikkelsen, Hans Christian Wulf
Journal	Acta dermato-venereologica (Acta Derm Venereol) Vol. 97 Issue 5 Pg. 617-621 (May 08 2017) ISSN: 1651-2057 [Electronic] Sweden
PMID	28093604 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References	Photosensitizing Agents methyl 5-aminolevulinate Aminolevulinic Acid Fluorouracil
Topics	Administration, Cutaneous Aged Aged, 80 and over Aminolevulinic Acid (administration & dosage, adverse effects, analogs & derivatives) Combined Modality Therapy Denmark Female Fluorouracil (administration & dosage, adverse effects) Humans Keratosis, Actinic (diagnosis, drug therapy) Male Middle Aged Photochemotherapy (adverse effects, methods) Photosensitizing Agents (administration & dosage, adverse effects) Remission Induction Skin (pathology, radiation effects) Sunlight (adverse effects) Time Factors Treatment Outcome Wound Healing (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!