Abstract |
This work aimed at estimating the kinetic parameters, and hence cumulated activity (AC), of a diagnostic/therapeutic convergence radiopharmaceutical, namely 64Cu-/177Lu-labeled antibody (64Cu-/177Lu- cetuximab), that acts as anti- epidermal growth factor receptor. Methods: In mice bearing esophageal squamous cell carcinoma tumors, to estimate uptake (K), release rate constant (kR), and hence AC, a kinetic model analysis was applied to recently published biodistribution data of immuno-PET imaging with 64Cu-cetuximab and of small-animal SPECT/CT imaging with 177Lu-cetuximab, including blood and TE-8 tumor. Results: K, kR, and AC were estimated to be 0.0566/0.0593 g⋅h-1⋅g-1, 0.0150/0.0030 h-1, and 2.3 × 1010/4.1 × 1012 disintegrations (per gram of TE-8 tumor), with an injected activity of 3.70/12.95 MBq, for 64Cu-/177Lu- cetuximab, respectively. Conclusion: A model is available for comparing kinetic parameters and AC of the companion diagnostic/therapeutic 64Cu-/177Lu- cetuximab that may be considered as a step for determining whether one can really use the former to predict dosimetry of the latter.
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Authors | Eric Laffon, Matthieu Thumerel, Jacques Jougon, Roger Marthan |
Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 58
Issue 6
Pg. 888-890
(06 2017)
ISSN: 1535-5667 [Electronic] United States |
PMID | 28082435
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2017 by the Society of Nuclear Medicine and Molecular Imaging. |
Chemical References |
- Antibodies, Monoclonal
- Copper Radioisotopes
- Radioisotopes
- Radiopharmaceuticals
- Lutetium
- ErbB Receptors
|
Topics |
- Animals
- Antibodies, Monoclonal
(pharmacokinetics)
- Carcinoma, Squamous Cell
(diagnostic imaging, metabolism, pathology)
- Cell Line, Tumor
- Computer Simulation
- Copper Radioisotopes
(pharmacokinetics)
- ErbB Receptors
(metabolism)
- Esophageal Neoplasms
(diagnostic imaging, metabolism, pathology)
- Lutetium
(pharmacokinetics)
- Metabolic Clearance Rate
- Mice
- Models, Biological
- Positron-Emission Tomography
(methods)
- Radiation Dosage
- Radioisotopes
(pharmacokinetics)
- Radiopharmaceuticals
(pharmacokinetics)
- Tissue Distribution
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