[The research of proteome profiling change of 1-bromopropane poisoning cases].

Abstract

Objective: This study was mainly focused on styudy on he proteome profile change between exposure to 1-Bromopropane (1-BP) and 1-BP poisoning. Methods: The samples of serums from exposure to 1-BP and 1-BP poisoning were collected and analyzed through Label free proteome technology platform. The differently expressed proteins between the two groups were quantified and identified, followed by function analysis by bioinformatics. Results: 127 proteins over 2 fold-change were selected, in which 39 proteins were up-regulated and 88 proteins were down-regulated. These different-ly expressed proteins were mainly involved in the process of enzyme active regulation, inflammatory reaction, protein modification, stress response, coagulation, transport. Conclusion: The differently expressed proteins provided the potential protein biomarkers for the early diagnosis of 1-BP poisoning and was beneficial for clinical diagnosis of 1-BP and understanding of the mechanism of 1-BP poisoning.

• Authors: R M Miao, B M Ding, Y Y Zhang, W M Wu, D H You, Z H Fang, R Zhao
• Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 34 Issue 11 Pg. 835-838 (Nov 20 2016) ISSN: 1001-9391 [Print] China
• PMID: 28043272 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Hydrocarbons, Brominated
• Proteome
• 1-bromopropane

Topics

• Biomarkers
• Down-Regulation
• Gene Expression Profiling
• Humans
• Hydrocarbons, Brominated (poisoning)
• Proteome
• Proteomics
• Up-Regulation