Metformin Attenuates Cognitive Impairments in Hypoxia-Ischemia Neonatal Rats via Improving Remyelination.

Abstract

Perinatal hypoxia-ischemia (H/I) causes brain injury and myelination damage. Finding efficient methods to restore myelination is critical for the recovery of brain impairments. By applying an H/I rat model, we demonstrate that metformin (Met) treatment significantly ameliorates the loss of locomotor activity and cognition of H/I rat in the Morris water maze and open field task tests. After administration of Met to H/I rat, the proliferation of Olig2+ oligodendrocyte progenitor cells and the expression of myelin basic protein are obviously increased in the corpus callosum. Additionally, the myelin sheaths are more compact and the impairments are evidently attenuated. These data indicate that Met is beneficial for the amelioration of H/I-induced myelination and behavior deficits.

• Authors: Boxiang Qi, Libao Hu, Lei Zhu, Lei Shang, Liping Sheng, Xuecheng Wang, Na Liu, Nana Wen, Xiaohe Yu, Qihong Wang, Yujia Yang
• Journal: Cellular and molecular neurobiology (Cell Mol Neurobiol) Vol. 37 Issue 7 Pg. 1269-1278 (Oct 2017) ISSN: 1573-6830 [Electronic] United States
• PMID: 28035478 (Publication Type: Journal Article, Retracted Publication)

Chemical References

• Metformin

Topics

• Animals
• Animals, Newborn
• Cognitive Dysfunction (metabolism, pathology, prevention & control)
• Hypoxia-Ischemia, Brain (metabolism, pathology, prevention & control)
• Maze Learning (drug effects, physiology)
• Metformin (pharmacology, therapeutic use)
• Random Allocation
• Rats
• Remyelination (drug effects, physiology)