Isolation and characterization of 2-pyridone alkaloids and alloxazines from Beauveria bassiana.

Abstract

Two novel compounds bearing heterocyclic nitrogen, 2-pyridone alkaloid (1) and alloxazine derivative (2), along with the known pretenellin B (3), pyridovericin (4) and lumichrome (5) were isolated from a culture of the entomopathogenic fungal strain Beauveria bassiana. The chemical structures of 2-pyridone alkaloid and alloxazine derivative were established on the basis of the interpretation of spectroscopic data. The isolated compounds were evaluated in a panel of five cancer cell lines and pyridovericin exhibited cytotoxicity (IC50, μM) against cancer cell lines: HL-60 (25.9 ± 0.3), HCT8 (34.6 ± 3.6), MDA-MB435 (34.8 ± 3.8) and SF295 (31.1 ± 0.6). Considering that other pyridone compounds display good cytotoxic activity, it would be suggested to obtain new semi synthetic derivatives of pyridovericin, for the development of new cytotoxic chemical entities.

• Authors: W J Andrioli, A A Lopes, B C Cavalcanti, C Pessoa, N P D Nanayakkara, J K Bastos
• Journal: Natural product research (Nat Prod Res) Vol. 31 Issue 16 Pg. 1920-1929 (Aug 2017) ISSN: 1478-6427 [Electronic] England
• PMID: 28032511 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Antineoplastic Agents
• Flavins
• Monosaccharides
• Pyridones
• pyridovericin
• 7,8-dimethylalloxazine
• isoalloxazine
• 2-hydroxypyridine

Topics

• Alkaloids (chemistry, isolation & purification, pharmacology)
• Antineoplastic Agents (chemistry, pharmacology)
• Beauveria (chemistry, metabolism)
• Cell Line, Tumor
• Drug Screening Assays, Antitumor
• Flavins (chemistry, isolation & purification)
• Humans
• Molecular Structure
• Monosaccharides (chemistry)
• Pyridones (chemistry, isolation & purification, pharmacology)
• Secondary Metabolism