Abstract | OBJECTIVE: BACKGROUND: METHODS: Patients who had pre-mature wearing off of botulinum injection effect were evaluated before and after the administration of 2 drops of apraclonidine 0.5%-1% solution to each eye. Subjective patient impressions and examiner's impression of symptoms pre and post- apraclonidine administration were recorded. A blinded rater evaluated the videos and provided an independent assessment of the severity of symptoms pre- and post-administration, using a 0-4 scale. RESULTS: Our study included 7 patients (4 male) with a mean age of 61years and mean duration of blepharospasm of 3.6years. There was a subjective, albeit transient (about 2-4h) improvement in blepharospasm reported by all patients and by the examiner. The mean severity scores, based on blinded video ratings, showed a reduction from of 3.4 pre-administration to 2.3 post-administration of apraclonidine (p<0.025). No adverse effects were noted. CONCLUSIONS:
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Authors | Dhanya Vijayakumar, Subhashie Wijemanne, Joseph Jankovic |
Journal | Journal of the neurological sciences
(J Neurol Sci)
Vol. 372
Pg. 57-59
(Jan 15 2017)
ISSN: 1878-5883 [Electronic] Netherlands |
PMID | 28017248
(Publication Type: Journal Article, Video-Audio Media)
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Copyright | Copyright © 2016. Published by Elsevier B.V. |
Chemical References |
- Adrenergic alpha-2 Receptor Agonists
- Neurotoxins
- apraclonidine
- Botulinum Toxins
- Clonidine
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Topics |
- Adrenergic alpha-2 Receptor Agonists
(therapeutic use)
- Aged
- Blepharospasm
(drug therapy)
- Botulinum Toxins
(therapeutic use)
- Clonidine
(analogs & derivatives, therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Neurotoxins
(therapeutic use)
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