Abstract | BACKGROUND: METHODS AND RESULTS: CONCLUSIONS: In conclusion, CAD deficiency protects against atherosclerosis through inhibiting inflammation and macrophage apoptosis, which is partially through inactivation of the MEK-ERK1/2 signaling pathway. This finding provides a promising therapeutic target for treating atherosclerosis.
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Authors | Meng-Lin Chao, Junhong Guo, Wen-Lin Cheng, Xue-Yong Zhu, Zhi-Gang She, Zan Huang, Yong Ji, Hongliang Li |
Journal | Journal of the American Heart Association
(J Am Heart Assoc)
Vol. 5
Issue 12
(12 22 2016)
ISSN: 2047-9980 [Electronic] England |
PMID | 28007744
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. |
Chemical References |
- NF-kappa B
- Poly-ADP-Ribose Binding Proteins
- DFFB protein, human
- Deoxyribonucleases
- Dffb protein, mouse
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Topics |
- Animals
- Atherosclerosis
(genetics, metabolism)
- Blotting, Western
- Coronary Disease
(metabolism)
- Deoxyribonucleases
(genetics, metabolism)
- Fluorescent Antibody Technique
- Humans
- In Situ Nick-End Labeling
- MAP Kinase Signaling System
- Mice
- Mice, Knockout, ApoE
- NF-kappa B
(metabolism)
- Phosphorylation
- Plaque, Atherosclerotic
(metabolism, pathology)
- Poly-ADP-Ribose Binding Proteins
(genetics, metabolism)
- Real-Time Polymerase Chain Reaction
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