Definitive carbon-ion radiotherapy for locally advanced parotid gland carcinomas.

Abstract

BACKGROUND:

The purpose of this study was to present our evaluation of the safety and efficacy of carbon-ion radiotherapy (C-ion RT) for locally advanced parotid gland carcinomas.

METHODS:

Clinicopathological features and outcomes were evaluated in 46 patients receiving C-ion RT for parotid gland carcinomas.

RESULTS:

Sixteen patients had adenoid cystic carcinoma; 8 had adenocarcinoma, 8 had mucoepidermoid carcinoma, and 14 had other carcinomas. T2, T3, T4a, and T4b diseases were diagnosed in 3, 18, 8, and 17 patients, respectively. C-ion RT was provided to 25 patients as the primary treatment, to 20 patients for local recurrences after surgery, and to 1 patient for residual tumor after surgery. During follow-up (median duration, 62 months), 5-year local control and overall survival (OS) rates were 74.5% and 70.1%, respectively. Of the 30 patients without facial nerve palsy before C-ion RT, 25 showed no radiation-induced facial nerve palsy.

CONCLUSION:

C-ion RT is effective and has acceptable toxicity levels for locally advanced parotid gland carcinomas. © 2016 Wiley Periodicals, Inc. Head Neck 39: 724-729, 2017.

• Authors: Masashi Koto, Azusa Hasegawa, Ryo Takagi, Hiroaki Ikawa, Kensuke Naganawa, Jun-Etsu Mizoe, Keiichi Jingu, Hirohiko Tsujii, Hiroshi Tsuji, Tadashi Kamada, Yoshitaka Okamoto, Organizing Committee for the Working Group for Head and Neck Cancer
• Journal: Head & neck (Head Neck) Vol. 39 Issue 4 Pg. 724-729 (04 2017) ISSN: 1097-0347 [Electronic] United States
• PMID: 28006083 (Publication Type: Comparative Study, Evaluation Study, Journal Article)
• Copyright: © 2016 Wiley Periodicals, Inc.

Topics

• Adenocarcinoma (diagnosis, mortality, radiotherapy)
• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Analysis of Variance
• Carcinoma, Adenoid Cystic (diagnosis, mortality, radiotherapy)
• Carcinoma, Mucoepidermoid (diagnosis, mortality, radiotherapy)
• Cohort Studies
• Disease-Free Survival
• Female
• Heavy Ion Radiotherapy (methods)
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Neoplasm Invasiveness (pathology)
• Neoplasm Staging
• Organ Sparing Treatments
• Parotid Neoplasms (mortality, pathology, radiotherapy)
• Prognosis
• Proportional Hazards Models
• Radiation Tolerance
• Radiotherapy Dosage
• Retrospective Studies
• Risk Assessment
• Survival Analysis
• Treatment Outcome
• Young Adult