Delphinidin Prevents Muscle Atrophy and Upregulates miR-23a Expression.

Abstract	Delphinidin, one of the major anthocyanidins, shows protective effects against a variety of pathologies, including cancer, inflammation, and muscle atrophy. The purpose of this study was to determine the preventive mechanism of delphinidin on disuse muscle atrophy. In vitro and in vivo models were used to validate the effects of delphinidin on the expression of MuRF1, miR-23a, and NFATc3. Delphinidin suppressed the upregulation of MuRF1 (1.77 ± 0.05 vs 1.03 ± 0.17, P < 0.05) expression and inhibited the downregulation of miR-23a (0.56 ± 0.05 vs 0.94 ± 0.06, P < 0.05) and NFATc3 (0.61 ± 0.02 vs 1.02 ± 0.08, P < 0.01) expression in dexamethasone-treated C2C12 cells. In gastrocnemius, muscle weight loss was prevented by oral administration of delphinidin. Moreover, delphinidin suppressed MuRF1 (3.35 ± 0.13 vs 2.26 ± 0.3, P < 0.01) expression and promoted miR-23a (0.58 ± 0.15 vs 2.25 ± 0.29, P < 0.001) and NFATc3 (0.85 ± 0.17 vs 1.54 ± 0.13, P < 0.001) expressions. Delphinidin intake may prevent disuse muscle atrophy by inducing miR-23a expression and suppressing MuRF1 expression.
Authors	Motoki Murata, Haruna Nonaka, Satomi Komatsu, Megumi Goto, Mai Morozumi, Shuhei Yamada, I-Chian Lin, Shuya Yamashita, Hirofumi Tachibana
Journal	Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 65 Issue 1 Pg. 45-50 (Jan 11 2017) ISSN: 1520-5118 [Electronic] United States
PMID	28000445 (Publication Type: Journal Article)
Chemical References	Anthocyanins Glucocorticoids MicroRNAs Mirn23b microRNA, mouse Muscle Proteins NFATC Transcription Factors Nfatc3 protein, mouse Tripartite Motif Proteins Trim63 protein, mouse Ubiquitin-Protein Ligases delphinidin
Topics	Animals Anthocyanins (administration & dosage) Glucocorticoids (adverse effects) Humans Male Mice Mice, Inbred C57BL MicroRNAs (genetics, metabolism) Muscle Proteins (genetics, metabolism) Muscle, Skeletal (drug effects, metabolism) Muscular Atrophy (drug therapy, genetics, metabolism) NFATC Transcription Factors (genetics, metabolism) Tripartite Motif Proteins (genetics, metabolism) Ubiquitin-Protein Ligases (genetics, metabolism) Up-Regulation (drug effects)

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