SHORT-TERM FINDINGS ON OPTICAL COHERENCE TOMOGRAPHY AND MICROPERIMETRY IN CHRONIC CENTRAL SEROUS CHORIORETINOPATHY PATIENTS TREATED WITH HALF-DOSE PHOTODYNAMIC THERAPY.

Abstract

PURPOSE:

To assess the short-term outcome of and possible temporary vision loss after half-dose verteporfin photodynamic therapy (PDT) in patients with chronic central serous chorioretinopathy (cCSC).

METHODS:

In this prospective study, 14 eyes of 13 cCSC patients who underwent half-dose PDT were included. Patients received spectral-domain optical coherence tomography (OCT) imaging and microperimetry before PDT on the day of treatment and 1 week after treatment.

RESULTS:

Five patients (38%) reported worsening of visual complaints in the week after half-dose PDT. No significant changes in both central foveal thickness, height of subretinal fluid, and choroidal thickness on optical coherence tomography imaging and retinal sensitivity on microperimetry were observed, neither in the patients who did not experience worsening of visual symptoms, nor in those who did.

CONCLUSION:

Worsening of visual complaints can occur in a noteworthy number of cCSC patients in the first week after half-dose verteporfin PDT. Despite the fact that no significant short-term changes on both optical coherence tomography and microperimetry have been detected in this study, the assessment could be of importance for the long-term outcome of treatment and needs further investigation.

• Authors: Elon H C van Dijk, Greet Dijkman, Thomas Theelen, Carel B Hoyng, Camiel J F Boon
• Journal: Retinal cases & brief reports (Retin Cases Brief Rep) 2018 Fall Vol. 12 Issue 4 Pg. 266-271 ISSN: 1937-1578 [Electronic] United States
• PMID: 27997459 (Publication Type: Journal Article)

Chemical References

• Photosensitizing Agents
• Porphyrins
• Verteporfin

Topics

• Adult
• Aged
• Central Serous Chorioretinopathy (drug therapy, physiopathology)
• Female
• Humans
• Male
• Middle Aged
• Photochemotherapy (adverse effects, methods)
• Photosensitizing Agents (adverse effects)
• Porphyrins (adverse effects)
• Prospective Studies
• Tomography, Optical Coherence (methods)
• Verteporfin
• Visual Field Tests
• Visual Fields (physiology)