Non-islet cell tumor hypoglycemia caused by a big insulin-like growth factor II- producing hepatocellular carcinoma:an autopsy case report.

Abstract

A 73-year-old man with a hepatocellular carcinoma was admitted to our hospital. He suffered from recurrent severe hypoglycemia. An autopsy was performed after his death. Anti-insulin-like growth factor II (IGF-II) monoclonal antibody immunostaining of the hepatocellular carcinoma was positive. Western immunoblot analysis of the serum revealed highly elevated IGF-II. Therefore, we diagnosed this case as a non-islet cell tumor hypoglycemia caused by a big IGF-II-producing hepatocellular carcinoma.

• Authors: Hirohito Naruse, Norihiko Shimoyama, Tsugumi Satoh, Yoshiya Yamamoto, Kazuteru Hatanaka, Taiki Kudo, Masayoshi Ohno, Kazuharu Suzuki, Hajime Hirata, Marina Suzuki
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 113 Issue 12 Pg. 2057-2066 ( 2016) ISSN: 0446-6586 [Print] Japan
• PMID: 27916774 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Insulin-Like Growth Factor II

Topics

• Aged
• Autopsy
• Carcinoma, Hepatocellular (complications, diagnostic imaging)
• Humans
• Hypoglycemia (etiology)
• Insulin-Like Growth Factor II (biosynthesis)
• Liver Neoplasms (complications, diagnostic imaging, pathology)
• Male
• Tomography, X-Ray Computed