Safety of Local Intracutaneous Lidocaine Anesthesia Used by Dermatologic Surgeons for Skin Cancer Excision and Postcancer Reconstruction: Quantification of Standard Injection Volumes and Adverse Event Rates.

Abstract

BACKGROUND:

Intracutaneous lidocaine is used for anesthesia in dermatologic surgery for skin cancer excision and repair with exceedingly low incidence of reported adverse events.

OBJECTIVE:

To measure (1) the quantity of lidocaine typically used for facial skin cancer excision and reconstruction; and (2) the frequency and character of associated adverse events.

METHODS:

Survey study of dermatologic surgeons with longitudinal reporting. Reported practice during 10 business days: (1) mean volume of 1% lidocaine per skin cancer excision; (2) maximum per excision; (3) mean per reconstruction; and (4) maximum per reconstruction.

RESULTS:

A total of 437 of 1,175 subjects contacted (37.2%) responded. Mean per excision was 3.44 mL (SD: 2.97), and reconstruction 11.70 mL (10.14). Maximum per excision was 6.54 mL (4.23), and reconstruction was 15.85 mL (10.39). No cases of lidocaine toxicity were reported, diagnosed, or treated. Incidence of adverse events possibly anesthesia related was >0.15%, with most (0.13%) being mild cases of dizziness, drowsiness, or lightheadedness from epinephrine tachycardia.

CONCLUSION:

Toxicity associated with local anesthesia other than lidocaine was not studied. Volumes of lidocaine in skin cancer excision and repair are modest and within safe limits. Lidocaine toxicity is exceedingly rare to entirely absent. For comparable indications, lidocaine is safer than conscious sedation or general anesthesia.

• Authors: Murad Alam, Matthew R Schaeffer, Amelia Geisler, Emily Poon, Scott W Fosko, Divya Srivastava
• Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 42 Issue 12 Pg. 1320-1324 (Dec 2016) ISSN: 1524-4725 [Electronic] United States
• PMID: 27893492 (Publication Type: Journal Article)

Chemical References

• Anesthetics, Local
• Lidocaine
• Epinephrine

Topics

• Anesthesia, Local (adverse effects, methods)
• Anesthetics, Local (administration & dosage, adverse effects)
• Cross-Sectional Studies
• Epinephrine (administration & dosage, adverse effects)
• Head and Neck Neoplasms (surgery)
• Humans
• Injections, Intradermal
• Lidocaine (administration & dosage, adverse effects)
• Longitudinal Studies
• Mohs Surgery
• Patient Safety
• Practice Patterns, Physicians' (statistics & numerical data)
• Plastic Surgery Procedures
• Skin Neoplasms (surgery)
• United States