Abstract | BACKGROUND: METHODS: We analyzed the clinical records of NSCLC patients treated with afatinib between May 2014 and February 2015. RESULTS: The records of a total of 73 patients (27 men, 46 women) with a median age of 69 years (range: 42-85 years) were analyzed. Afatinib was administered to 11 patients as a first-line therapy, but it was predominantly administered as a fifth-line or beyond therapy (32 cases, 43.8%). The overall response rates for afatinib as a first-line therapy and beyond second-line therapy were 80% (95% confidence interval [CI]: 55.2-100.0%) and 27.1% (95% CI: 14.5-39.7%), respectively. The main toxicities grade >3 included diarrhea (8.2%), skin rash (6.8%), nausea (6.8%), and appetite loss (6.8%). A low body surface area (BSA) (<1.5m2) was significantly associated with a higher frequency of diarrhea grade >2, compared with a higher BSA (≥ 1.5m2). Forty-eight patients (63.0%) were treated without a dose reduction of afatinib. CONCLUSIONS: Although the survival benefit with afatinib remains unclear, our observational analysis demonstrated the feasibility of using afatinib for EGFR-mutated NSCLC in clinical practice. In particular, a relatively high level of drug delivery is possible. In addition, a lower BSA may be a predictor of diarrhea in patients treated with afatinib.
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Authors | Yosuke Wada, Shigeru Koyama, Hiroshi Kuraishi, Takashige Miyahara, Fumiaki Yoshiike, Toshihiko Agatsuma, Ryouhei Yamamoto, Yasushi Ono, Toshiro Suzuki, Tsutomu Hachiya, Daisuke Gomi, Kazunari Tateishi, Masayuki Hanaoka, Tomonobu Koizumi |
Journal | Respiratory investigation
(Respir Investig)
Vol. 54
Issue 6
Pg. 462-467
(Nov 2016)
ISSN: 2212-5353 [Electronic] Netherlands |
PMID | 27886858
(Publication Type: Journal Article, Observational Study)
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Copyright | Copyright © 2016 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Quinazolines
- Radiation-Sensitizing Agents
- Afatinib
- EGFR protein, human
- ErbB Receptors
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Topics |
- Adult
- Afatinib
- Aged
- Aged, 80 and over
- Body Surface Area
- Carcinoma, Non-Small-Cell Lung
(drug therapy, genetics, pathology)
- Diarrhea
(chemically induced)
- ErbB Receptors
(genetics)
- Feasibility Studies
- Female
- Gene Expression Regulation
- Humans
- Japan
- Lung Neoplasms
(drug therapy, genetics, pathology)
- Male
- Middle Aged
- Mutation
- Neoplasm Staging
- Quinazolines
(administration & dosage, adverse effects, therapeutic use)
- Radiation-Sensitizing Agents
(administration & dosage, adverse effects, therapeutic use)
- Retrospective Studies
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